Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• ID
  MGI:3043718

Genes

Gene	Assay Type
Splq9	visible phenotype
D17Mit124	PCR amplified length variant
D17Mit10	PCR amplified length variant
Scfq4	visible phenotype
Epfq3	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.
  
  On mouse Chromosome 17, QTLs for spleen weight (Splq9), subcutaneous fat pad weight (Scfq4), and epididymal fat pad weight (Epfq3) were identified in an interval between D17Mit124 and D17Mit10. Splq9 mapped to 21.9 cM (LOD=3.4) with L6-derived alleles conferring recessively inherited decrease in spleen weight. Scfq4 mapped to 21.9 cM (LOD=4.1) with L6-derived alleles conferring dominantly inherited decrease in subcutaneous fat pad weight. Epfq3 mapped to 21.9 cM (LOD=3.8) with L6-derived alleles conferring recessively inherited decrease in epididymal fat pad weight.