Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  5
• Reference
  J:85407 Percec I, et al., An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse. Genetics. 2003 Aug;164(4):1481-94
• ID
  MGI:3043981

Genes

Gene	Assay Type
Xiaf2
D5Mit214	PCR amplified length variant
D5Mit43	PCR amplified length variant
Zfp68	reported elsewhere
Hmgb1	reported elsewhere
Brca2	reported elsewhere
Hspb1	reported elsewhere
Zscan21	reported elsewhere

Notes

• Experiment
  The Xiaf2 and Xiaf3 dominant mutations were identified in an ENU mutagenesis screen for X chromosome inactivation mutations. The authors identified two candidate regions in the mouse genome that transmit the mutant phenotype to the offspring. One is on Chromosome 5 between D5Mit214 and D5Mit43 (Xiaf2), where as the other is on proximal 10 between D10Mit80 and D10Mit138 (Xiaf3). The Xiaf2 candidate region spans 30 cM on proximal mouse Chromosome 5 from approximately 70 cM - 103 cM. The Xiaf3 candidate region spans the distal 23 cM of mouse Chromosome 10 from approximately 4 cM - 34 cM.
  
  Candidate genes in the region of Xiaf2 include Zfp70, Hmgb1, Brca2, Hspb1 (Hsp25), and Zipro1. Candidate genes in the region of Xiaf3 include Hmg20b (Braf35), Hdac2, Mbd3, Dnmt3l, and Zfa