Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  9
• Reference
  J:87327 Cho KI, et al., Fine mapping of the circling (cir) gene on the distal portion of mouse chromosome 9. Comp Med. 2003 Dec;53(6):642-8
• ID
  MGI:3044211

Genes

Gene	Assay Type
cir	visible phenotype
D9Mit182	PCR amplified length variant
D9Mit51	PCR amplified length variant
D9Mit79	PCR amplified length variant
D9Mit310	PCR amplified length variant
D9Mit212	PCR amplified length variant
D9Mit184	PCR amplified length variant
D9Mit116	PCR amplified length variant
D9Mit15	PCR amplified length variant
D9Mit38	PCR amplified length variant
D9Mit20	PCR amplified length variant
D9Mit243	PCR amplified length variant
D9Mit16	PCR amplified length variant
D9Mit55	PCR amplified length variant
D9Mit125	PCR amplified length variant
D9Mit281	PCR amplified length variant
Map4	reported elsewhere
Ltf	reported elsewhere
Camkl	reported elsewhere
Zic4	reported elsewhere
Zic1	reported elsewhere
Lamb2	reported elsewhere
Myl3	reported elsewhere

Notes

• Experiment
  428 mice from a (ICR-cir/cir x C57BL/6J)F1 x ICR-cir/cir backcross population were typed for 114 microsatellite markers. The cir mutation mapped to 61 cM on mouse Chromosome 9 between D9Mit116 and D9Mit38. The order of markers near cir are as follows:
  
  cent - D9Mit182 - D9Mit51/D9Mit79/D9Mit310 - D9Mit212/D9Mit184 - D9Mit116/D9Mit15 - cir - D9Mit38 - D9Mit20 - D9Mit243 - D9Mit16 - D9Mit55/D9Mit125 - D9Mit281 - tel
  
  A YAC chromosome walk was performed using D9Mit116/D9Mit15 and D9Mit38 as starting points.Sequences from the right end of YAC 457G1 showed sequence similarity to Ltf and Mtap4. The position of Ltf was determined to be at 60 cM on chromosome 9. The order of genes near the cir critical region was determined to be cent - Mtap4 - Myl13 - Ltf - tel. This region corresponds to human Chromosome 3p21 and the order of the genes is conserved. Candidate genes for cir include Mtap4, Camkl, Zic1, Zic, Lamb2, and Myl3.