Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:89536 Glant TT, et al., Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis. Am J Med Sci. 2004 Apr;327(4):188-95
• ID
  MGI:3044947

Genes

Gene	Assay Type
Pgia37	resistance/susceptibility
Cia1	resistance/susceptibility
Pgia20	resistance/susceptibility

Notes

• Experiment
  Linkage analysis at an average resolution of 10 cM was performed on 3 separate mouse crosses to map QTLs associated with proteoglycan-induced arthritis (PGIA) and collagen-induced arthritis (CIA).
  
  559 (BALB/c x DBA/2)F2 MHC-matched animals and 402 (BALB/c x DBA/1J)F2 MHC-unmatched animals were analyzed for linkage to PGIA.
  
  537 (BALB/c x DBA/1J)F2 animals were analyzed for linkage to CIA. With respect to PGIA, parental strain BALB/c is highly susceptible whereas parental strains DBA/2 and DBA/1J are fullyresistant. As expected, (BALB/c x DBA/2)F1 hybrids are resistant to PGIA, but interestingly (BALB/c x DBA/1J)F1 hybrids are susceptible to PGIA. This is unusual because the BALB/c allele typically exhibits recessive susceptibility to disease, but thisisnot the case with the cross to DBA/1J.
  
  With respect to CIA, parental strain DBA/1J is highly susceptible whereas parental strains BALB/c and DBA/2 are fully resistant. All F1s exhibited susceptibility to CIA.
  
  Linkage to arthritis susceptibility, LOD=21.0, designated as mCia1 in Fig 3 and assigned symbol Cia1; and PGIA (LOD=6.0) were detected at the H2 locus on mouse Chromosome 17 in the (BALB/c x DBA/1J)F2 MHC-unmatched population. The PGIA locus has been mapped in previous experiments (J:78168) and is named Pgia37.
  
  Pgia20 mapped to distal mouse Chromosome 17 in (BALB/c x DBA/1J)F2 animals (independent of MHC), and is involved in PGIA susceptibility and severity.