Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:87921 Le TH, et al., Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency. Hypertension. 2004 Feb;43(2):445-51
• ID
  MGI:3046354

Genes

Gene	Assay Type
Agtr1a
msrvh1	visible phenotype
D3Mit103	PCR
D3Mit345	PCR
D3Mit57	PCR

Notes

• Experiment
  Agtr1 null mutant (-/-) mice were obtained from mating 129/J and C57BL/6J Agtr1 mice that were heterozygous for the targeted mutation. The null mutant mice (129/J X C57BL/6J)F1 were backcrossed to C57BL/6J (-/-) for mapping experiments to identify genes from C57BL/6J that modify the Agtr1 phenotype. From the aforementioned cross 119 mice were informative in mapping msrvh1 to mouse Chromosome 3. Locus msrvh1mapped with D3Mit345 (LOD 3.8) and was flanked by D3Mit103 and D3Mit57. At 55 cM msrvh1 maps distal to Agtr1 and therefore is not the same locus. A LRS (likelihood rato statistic) of 17.8 was also observed with D3mit345.