Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  14
• Reference
  J:89229 Ulbrich M, et al., Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse. Neuroreport. 2002 Mar 25;13(4):535-9
• ID
  MGI:3046424

Genes

Gene	Assay Type
D14Mit154	PCR
wrmod1	visible phenotype
D14Mit105	PCR
Rb1	reported elsewhere
Pcdh8	reported elsewhere
Tnfsf11	reported elsewhere
Ednrb	reported elsewhere

Notes

• Experiment
  Animals from a (C57BL/6J-wr x CAST/Ei)F2 intercross were used to map modifiers of the wobbler (wr) mutation. 46 microsatellite markers were screened by interval haplotype analysis in 18 severely affected homozygous mutant F2 animals. A modifier of wr mapped to mouse Chromosome 14. This locus is named wrmod1 and is CAST/Ei-derived. The effect of wrmod1 is aggravated neurodegeneration, increased astrogliosis, and enhanced progression of neurodegeneration.
  
  The Authors used Consomic lines between CAST/Ei and C57BL/6J to confirm and localize wrmod1 to a 29 cM interval between D14Mit154 (21.5 cM) and D14Mit105 (48 cM). The consomic line carries CAST/Ei-derived chromosome 14 DNA on a C57BL/6J genetic background.
  
  The wrmod1 locus is syntenic to human Chromosome 13q14-q22. Previously identified genes located in the wrmod1 interval are Rb1 (41 cM), Pcdh8 (43 cM), Tnfsf11 (45 cM), and Ednrb (51 cM).