Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:66465 Vadasz C, et al., Mapping of quantitative trait loci for ethanol preference in quasi-congenic strains. Alcohol. 2000 Feb;20(2):161-71
• ID
  MGI:3046821

Genes

Gene	Assay Type
Alprf	visible phenotype
D15Mit159	PCR amplified length variant
D15Mit34	PCR amplified length variant
D15Mit242	PCR amplified length variant
Tymp	reported elsewhere
Cntn1	reported elsewhere
Kif21a	reported elsewhere
Pou6f1	reported elsewhere
Aqp5	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on a series of Recombinant QTL Introgression (RQI) strains (derived from C57BL/6ByJ and BALB/cJ) to identify QTLs associated with alcohol preference. Male animals from each of 13 RQI strains were tested for 12% alcohol preference and genotyped at 244 polymorphic loci with an average spacing of 6.6 cM. Progenitor strain C57BL/6ByJ exhibits higher alcohol preference than progenitor strain BALB/cJ.
  
  Significant linkage to 12% alcohol preference (P<0.0002) mapped to a region of mouse Chromosome 15 spanning markers D15Mit159 (49.6 cM), D15Mit34 (52.2 cM), and D15Mit242 (55.6 cM). The experiment was done in duplicate and the same 3 chromosome 15 markers were detected each time. This locus is named Alprf (alcohol preference.) BALB/cJ-derived alleles confer increased alcohol preference at this locus. Potential candidate genes mapping near Alprf include Ecgf1 (51.6 cM), Cntn1 (55.1 cM), Kif21a (55.1 cM), Pou6f1 (56.6 cM), and Aqp5 (56.8 cM).