Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  X
• Reference
  J:71307 Liu X, et al., Characterization of a major X-linked quantitative trait locus influencing body weight of mice. J Hered. 2001 Jul-Aug;92(4):355-7
• ID
  MGI:3050785

Genes

Gene	Assay Type
Bw19	visible phenotype
DXMit50	PCR amplified length variant
DXMit25	PCR amplified length variant

Notes

• Experiment
  Body weight QTL Bw19 was originally mapped to 26.4 cM on mouse Chromosome X in a (HI x LI)F1 x LI backcross population. Parental strain HI exhibits high body weight whereas parental strain LI exhibits low body weight. In this study authors use a partially congenic line carrying HI-derived DNA between markers DXMit50 (14.1 cM) and DXMit25 (27.8 cM) on an LI genetic background to assess the effect of Bw19 on 17 growth related traits.
  
  Results show that Bw19 exerts the most significant effect on early growth rate from birth to 3 weeks of age. Bw10 also affects tail and body length- congenics carrying HI alleles at Bw19 display significantly higher tail and body lengths. Bw19 also increases organ weight at 10 weeks of age and increases total and daily food intake in animals bearing HI alleles.
  
  The Bw19 interval overlaps with previously identified QTLs Bdln1 (17 cM) and Bw1 (17 cM).