Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:68169 Cabib S, et al., Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model. Psychopharmacology (Berl). 1997 Jul;132(2):153-60
• ID
  MGI:3053608

Genes

Gene	Assay Type
Apsic3	visible phenotype
D10Mit11	PCR amplified length variant
Hal	reported elsewhere
Fdpsl5	reported elsewhere
Kcnc2	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed using 25 BXD/Ty recombinant inbred (RI) strains (derived from progenitor strains C57BL/6J and DBA/2J) to identify QTLs associated with stress. A mapping panel consisting of 1400 polymorphic loci was used to map the QTLs. 10-12 week old RI animals were subjected to repeated stress and administered a low dose of apomorphine, then climbing behavior was assessed. Parental strain DBA/2J exhibits significantly increased climbing behavior after stress and apomorphine administration compared to parental strain C57BL/6J. Apomorphine inhibits climbing behavior but the effect appears to be reduced in DBA/2J.
  
  Significant linkage was detected at 35 cM on mouse Chromosome 7 near D7Ncvs49 (P<0.001). This locus is named Apsic1 (apomorphine stress induced climbing 1).
  
  Apsic2 mapped to 55 cM on mouse Chromosome 9 near D9Ncvs55 (P<0.001).
  
  Apsic3 mapped to 49 cM on mouse Chromosome 10 near D10Mit11 (P<0.001). The Apsic3 interval spans 49 cM - 62 cM and explains 34% of the variance. Potential candidate genes for Apsic3 include Hal (49 cM), Fdpsl5 (51 cM), Kcnc2 (62 cM).
  
  Apsic4 mapped to 49 cM on mouse Chromosome 13 near Iapls2-6 (P<0.001). Potential candidate genes for Apsic4 include Crhbp and Arsb.
  
  In addition, several loci showed linkage at the P<0.05 significance level. These are at 48 cM on mouse Chromosome 1 (D1Ncvs43), 26 cM - 32 cM and 57 cM on mouse Chromosome 11 (D11Ncvs48 - Hist3, D11Ncvs79), 41 cM on mouse Chromosome 15 (D15Mit1), and 54 cM on mouse Chromosome 19 (D19Mit6).