Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  16
• Reference
  J:75540 Palmer AA, et al., Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genes. Behav Neurosci. 2002 Feb;116(1):126-37
• ID
  MGI:3054740

Genes

Gene	Assay Type
D16Mit84	PCR amplified length variant
Hmgb1-ps6	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 24 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains to identify QTLs associated with sensitivity to allopregnanolone-induced locomotor activity. A panel of 1,400 polymorphic markers was genotyped. Allopregnanolone has depressive and ataxic effects similar to ethanol. Female animals were injected intraperitoneally with allopregnanolone solution and observed for 30 minutes. At a concentration of 17 mg/kg allopregnanolone solution, parental strain DBA/2J exhibits increased locomotor activity at 15-20 minutes following treatment compared to C57BL/6J.
  
  79 loci showing association to allopregnanolone-induced locomotor activity at 17 mg/kg were identified at the statistical significance level of P<0.05. Of these, 22 loci showed association at the significance level of P<0.01. All loci are considered provisional. A few of the highest LOD scores identified were at 88.4 cM on mouse Chromosome 2 (LOD=2.12 at Odc-rs2), 23.2 cM on mouse Chromosome 1 (LOD=1.99 at D1Ncvs36), 34.2 cM on mouse Chromosome 16 (LOD=1.88 at D16Mit84, and at 19 cM on mouse Chromosome 16 (LOD=1.81 at Hmgb1-rs7).