Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:34745 Markel PD, et al., Quantitative trait loci for ethanol sensitivity in the LS x SS recombinant inbred strains: interval mapping. Behav Genet. 1996 Jul;26(4):447-58
• ID
  MGI:3054745

Genes

Gene	Assay Type
Lore2	visible phenotype
D2Mit21	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on a series of LSXSS recombinant inbred (RI) strains to identify QTLs associated with LORR (loss of righting response) and blood ethanol concentration (BEC). 124 polymorphic markers were used for genotyping. Parental strains LS (long sleep) and SS (short sleep) differ significantly with respect to ethanol sensitivity- LS exhibits a long sleep time after ethanol administration whereas SS exhibits a short sleep time.
  
  11 provisional QTLs for LORR and 5 provisional QTLs for BEC were identified using multipoint analysis. The strongest locus mapped to 80 cM on mouse Chromosome 2 and exceeded the threshold for genome-wide significance (P<0.001). This locus is named Lore2 and shows linkage to D2Mit21 at 80 cM. Lore2 explains 40%of the genotypic variance for LORR and 17% of the variance for BEC. Lore2 was also detected using interval mapping (P<0.0002).