Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:85847 Kokubu C, et al., Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1. Genetics. 2003 Sep;165(1):299-307
• ID
  MGI:3054778

Genes

Gene	Assay Type
Pax1
Foxa2
Nkx2-2
D2Neu1	PCR amplified length variant
D2Neu2	PCR amplified length variant
D2Neu3	PCR amplified length variant
D2Neu4	PCR amplified length variant
D2Neu5	PCR amplified length variant
D2Neu6	PCR amplified length variant
D2Neu7	PCR amplified length variant

Notes

• Experiment
  The Pax1^Un-s deletion interval was mapped using a BAC contig. The length of the Pax1^Un-s deletion is approximately 125 kb long. The 5' breakpoint is 50 kb upstream of exon 1 and the 3' breakpoint is 65 kb downstream of exon5. This region contains a deletion of all exons of Pax1, the last 2 exons of a putative Nkx2-2 antisense gene (authors designate this gene Asnkx2-2), and the last 2 exons of a putative Pax1 antisense gene (authors designate this gene Aspax1). The antisense genes do not appear to contain open reading frames.
  
  Nkx2-2 was found to be approximately 180 kb upstream of Pax1 and Foxa2 was found to be 672 kb downstream of Pax1.
  
  New STS markers D2Neu1-7 were used in this study.
  
  Thus, the order of markers and genes along mouse Chromosome2 are as follows: cent - Nkx2-2 - D2Neu1 - D2Neu2 - D2Neu3 - D2Neu4 - Pax1 - D2Neu5 - D2Neu6 - D2Neu7 - Foxa2 - tel