Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:75405 Babaya N, et al., Sequence analysis of Tnf as a candidate for Idd16. Autoimmunity. 2002 Feb;35(1):63-6
• ID
  MGI:3054990

Genes

Gene	Assay Type
Tnf	reported elsewhere
Idd16	resistance/susceptibility

Notes

• Experiment
  Tnf is considered a candidate gene for the diabetes susceptibility QTL Idd16 at 18 cM on mouse Chromosome 17. Sequence analysis of the Tnf coding region did not reveal difference between diabetes susceptible strain NOD and diabetes resistant strain CTS, however, analysis of the 5' upstream regulatory region revealed a SNP at nucleotide 3408. Resistant strain CTS carries an A allele at nucleotide 3408 whereas susceptible strain NOD carries a C allele. This nucleotide change results in a new GATA family binding site in the CTS transcript, which may explain the phenotypic difference between CTS and NOD.