Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  2
• Reference
  J:91636 Ewart-Toland A, et al., The genetics of cancer susceptibility: from mouse to man. Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:26-30
• ID
  MGI:3055773

Genes

Gene	Assay Type
Skts13	resistance/susceptibility

Notes

• Experiment
  The QTL interval of Skts13 (skin tumor susceptibility 13) shows synteny to a region of human Chromosome 20q13.2 associated with various tumors such as breast, ovarian, and colon tumors. Skts13 was previously identified in a series of backcrosses involving NIH/Ola, M. spretus, SEG/Pas, and SPRET/EI. A search for candidate genes was performed for the Skts13 interval and one gene, Skt6 (100 cM on mouse Chromosome 2), was found to exhibit differential expression between M. musculus and M. Spretus. In the orthologous human gene, SKT6, a polymorphism exists that is associated with increased risk for breast and prostate cancer. In addition, a large proportion of heterozygous colon tumors carry multiple copies of the disease-associated allele in humans.