Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  17
• Reference
  J:87679 Qin J, et al., Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells. Mol Cell Biol. 2004 Feb;24(4):1655-66
• ID
  MGI:3056157

Genes

Gene
H2-Ea

Notes

• Experiment
  Intron 4 of H2-Ea on mouse Chromosome 17 contains a 418 bp recombination hotspot exhibiting strong correlation to high frequency of DNA breaks during meiosis in testicular germ cells. This region exhibits a 4.6-fold greater number of DNA breaks comparedto flanking regions. The distribution of DNA breaks does not appear to be random. The majority of breaks are clustered in the first 3 52-bp bins of the hotspot region. Two different strains were used to assess DNA break frequency: B10.F-H2^pb1/(13R)J and B10.S-H2^t4/(9R)/J. The B10.F-H2^pb1/(13R)J strain exhibits an increased rate of DNA breaks in the H2-Ea hotspot region compared to strain B10.S-H2^t4/(9R)/J.