Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  10
• Reference
  J:85793 Bomar JM, et al., Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. (Erratum). Nat Genet. 2003 Nov;35(3):264-9
• ID
  MGI:3056351

Genes

Gene
Atcay
D10Mit140
D10Mit207
D10Mit7
D10Wad2
Dapk3
Map2k2
Mrpl54
Gna15

Notes

• Experiment
  The mouse jittery locus was fine mapped using approximately 3,000 animals from an F2 intercross between CAST/Ei and JIGR/DnJ-Atcay^ji gr. Animals were typed for markers between an interval defined by D10Mit140 and D10Mit207. The jittery interval was narrowed to an 800 kb region that is orthologous to an interval on human Chromosome 19p13.3 associated with Cayman ataxia. The order of genes in the mouse jittery critical region on chromosome 10 is as follows:
  
  cent - D10Mit7 - Map2k2/D10Wad2 - Dapk3 - Atcay - Mrpl54 - Gna15 - tel
  
  Southern blot analysis of genes within the jittery interval identified one particular gene showing DNA changes in jittery mutants. Sequence analysis showed that 3 different jittery mutants (jittery, hesitant, and sidewinder) allcarry mutations in this gene. This gene is Atcay.