Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  3
• Reference
  J:85785 Nomura R, et al., Genetic mapping of the absence of third molars in el mice to chromosome 3. J Dent Res. 2003 Oct;82(10):786-90
• ID
  MGI:3056796

Genes

Gene	Assay Type
am3
D3Mit141
Notch2	reported elsewhere
Ngf	reported elsewhere
Pitx2	reported elsewhere
Lef1	reported elsewhere
Egf	reported elsewhere
D3Mit216
D3Mit17

Notes

• Experiment
  Absence of third molars in mice was associated with D3Mit141 in EL mice. Absence of third molars occurs at an incidence of 97% in EL mice. Informative crosses involved MSM and EL mice. 15 (EL/Seac x MSM/Msf)F2 animals with missing M3 molars were genotypedfor 59 polymorphic markers across the genome. The region of highest association was found between D3Mit216 and D3Mit17. Genotyping chromosome 3 markers in 7 (El/Seac x MSM/Msf)F1 x El/Seac backcross mice with missing M3 and 15 (EL/Seac x MSM)F2 control mice with normal dentation supported this finding. Homozygosity for EL/Seac-derived alleles confer increased incidence of missing M3 molars. Potential candidate genes found in this region are Notch 2, Ngfb, Pitx2, Lef1, and Egf.
  
  Suggestive association tomissing M3 molars was also detected at 32 cM on mouse Chromosome 16 near D16Mit126 (x2=0.05).