Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  3
• Reference
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24
• ID
  MGI:3057347

Genes

Gene
Hps3
Insq3
Bglq3
Wt10q2
Fabp2
Ampd2

Notes

• Experiment
  The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.
  
  On mouse Chromosome 3, Hps3 (12.5 cM) showed differential expression between A/a and A/A^vy animals on the unrestricted diet. Diabesity QTL Insq3 (2.6 cM) maps near this candidate gene.Candidate genes for diabesity QTLs Bglq3 (49 cM) and Wt10q2 (61 cM) are Fabp2 (55 cM) and Ampd2 (50.4 cM). Fabp2 shows differential expression between the restricted and unrestricted diets on the A/a background and Ampd2 shows differential expression between the restricted and unrestricted diets on the A/A^vy background.