Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  10
• Reference
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24
• ID
  MGI:3487128

Genes

Gene
Igfbp3q2
Hsp90b1
Tle5
Mdm2
Insq4

Notes

• Experiment
  The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.
  
  On mouse Chromosome 10, candidate genes for diabesity QTL Igfp3q2 (46 cM) are Aes (43 cM) and Hsp90b1 (49 cM). Aes shows differential expression between A/a and A/A^vy animals on both the restricted and unrestricted diets while Hsp90b1 shows differential expression between the restricted and unrestricted diets on the A/A^vy background. At another locus, Mdm2 (66 cM) is a candidate gene for diabesity QTL Insq4 (59 cM). Mdm2 shows differential expression between the restricted and unrestricted diets on the A/a background.