Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  18
• Reference
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24
• ID
  MGI:3487135

Genes

Gene
Fgf1
Nidd2
Cd14
Bwq4

Notes

• Experiment
  The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.
  
  On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A^vy background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A^vy animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.