Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  4
• Reference
  J:92934 Treadwell JA, et al., Genetic segregation of brain gene expression identifies retinaldehyde binding protein 1 and syntaxin 12 as potential contributors to ethanol preference in mice. Behav Genet. 2004 Jul;34(4):425-39
• ID
  MGI:3511337

Genes

Gene	Assay Type
Stx12	reported elsewhere
Ap3q	reported elsewhere

Notes

• Experiment
  Six genes showing differential expression in the brains of ethanol-preferring strain C57BL/6J and ethanol-avoiding strain DBA/2J were identified using mRNA differential display. Two of the six mRNA sequences matched functionally known genes, Stx12 (60 cM) on mouse Chromosome 4 and Rlpb1 (39 cM) on mouse Chromosome 7. These genes were typed in 480 (C57BL/6 x DBA/2J)F2 mice and found to segregate with the ethanol preference phenotype.
  
  Rlbp1 shows significantly higher expression in the brains of alcohol-preferring F2 mice compared to alcohol-avoiding F2 mice. This effect is stronger in (C57BL/6J x DBA/2J)F2 animals compared to the reciprocal cross (DBA/2J x C57BL/6J)F2. Rlpb1 maps near a suggestive QTL for alcohol preference (D7Mit7, 54 cM) and hypnotic dose sensitivity (Mmpv1, 28 cM) mapped by Rodriguez et al, 1995.
  
  Stx12 shows significantly lower expression in the brains of alcohol-preferring F2 mice compared to alcohol-avoiding F2 mice. This effect is stronger in (C57BL/6J x DBA/2J)F2 animals compared to the reciprocal cross (DBA/2J x C57BL/6J)F2. Stx12 maps near a previously identified alcohol preference QTLs Ap3q (81 cM) and a previously identified suggestive QTL for alcohol consumption mapped by Phillips et al, 1994.