Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  5
• Reference
  J:94070 Stoddart CW, et al., A novel mouse Chr5 locus Diht controls dopamine-induced hypothermia. Mamm Genome. 2004 Nov;15(11):901-13
• ID
  MGI:3511964

Genes

Gene
D5Mit41
D5Mit26
D5Mit158
Diht
Oas1b

Notes

• Experiment
  148 (C3H/HeJArc x C3.PRI-Oas1b^Flv-r)F2 mice were inforamtive in mapping Diht to mouse chromosome 5 to a region defined by D5Mit41, D5Mit26 and D5Mit158. Importantly Diht maps to a location proximal to Oas1b^Flv. Parental strain C3.PRI-Oas1b^Flv-r is sensitive to dompamine- and apomorphine-induced hypothermia compared to parental strain C3H/HeJArc. F2 animals homozygous for C3H/HeJArc-derived alleles at Diht display decreased sensitivity to apomorphine-induced hypothermia compared to heterozygous F2 animals or F2 animals homozygous for C3.PRI-Oas1b^Flv-r-derived alleles.