Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:94028 Rocha JL, et al., A large-sample QTL study in mice: III. Reproduction. Mamm Genome. 2004 Nov;15(11):878-86
• ID
  MGI:3512188

Genes

Gene	Assay Type
Estoq4	visible phenotype
D1Mit180	PCR amplified length variant
D1Mit72	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 439 pregnant female animals from a (M16i x L6)F2 intercross to identify QTLs associated with reproductive traits. Parental strain M16i exhibits a higher ovulation rate and higher number of live fetuses at 10 weeks of gestation compared to L6, but parental strain L6 exhibits increased total fetal survival rate compared to M16i.
  
  On mouse Chromosome 1, linkage to total embryo survival mapped to 41 cM (LOD=3.5). This locus is named Estoq4 (embryo survival total QTL 4). The QTL interval of Estoq4 spans 29.8 cM - 49.5 cM and is flanked by markers D1Mit180 and D1Mit72. M16i-derived alleles confer decreased total embryo survival at Estoq4.