Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
• ID
  MGI:3512954

Genes

Gene	Assay Type
Fmgty1	visible phenotype
D1Nds2	PCR amplified length variant

Notes

• Experiment
  487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.
  
  Linkage to cortical thickness, shape factor, and standard deviation of outer fiber length (StdOFL) mapped to 59 cM on mouse Chromosome 1 near D1Nds2. This locus is designated Fmgty1 (femur geometry 1). C3H/HeJ-derived alleles confer increased cortical thickness compared to DBA/2J-derived alleles. BALB/cJ- and DBA/2J-derived alleles confer increased StdOFL compared to C57BL/6J- and C3H/HeJ-derived alleles. C57BL/6J- and C3H/HeJ-derived alleles confer increased shape factor compared to BALB/cJ- and DBA/2J-derived alleles.