Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  1
• Reference
  J:82019 Marshall KE, et al., In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biol. 2002;3(12):RESEARCH0078
• ID
  MGI:3513355

Genes

Gene
D1Mit122
Slc5a7

Notes

• Experiment
  Information from the Celera SNP database was used to screen for single nucleotide polymorphisms (SNP) in genes residing within alcohol withdrawal severity QTLs. Two suggestive QTL on proximal mouse Chromosome 1 and proximal mouse Chromosome 13 showing linkage to alcohol withdrawal severity were identified in a population of (C57BL/6J x DBA/2J)F2 animals (Buck et al 2002, J:91457). In this study the authors examined coding region variations between parental strains C57BL/6J and DBA/2J for a battery of genes located within the QTL intervals to identify possible candidates.
  
  A previously identified suggestive QTL mapped to proximal mouse Chromosome 1 at 20.6 cM near D1Mit122 (LOD=3.4), C57BL/6J-derived alleles confer increased alcohol withdrawal severity atthis locus. 121 genes spanning 125,385 bp around this locus were screened for SNPs differing between C57BL/6J and DBA/2J. Eight amino acid changes were identified in six different genes, one of which is Slc5a7. Slc5a7 may be considered a possible candidate, but while synteny to human SLC5A7 implies the mouse gene is within the chromosome 1 QTL interval Celera and MGI databases place Slc5a7 on mouse Chromosome 17. Further data is required before moving ahead with candidate gene analysis.