Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  13
• Reference
  J:82019 Marshall KE, et al., In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biol. 2002;3(12):RESEARCH0078
• ID
  MGI:3513356

Genes

Gene
D13Mit224
Habp4
Ptch1
Srd5a1
Zfp369
Hsd17b3

Notes

• Experiment
  Information from the Celera SNP database was used to screen for single nucleotide polymorphisms (SNP) in genes residing within alcohol withdrawal severity QTLs. Two suggestive QTL on proximal mouse Chromosome 1 and proximal mouse Chromosome 13 showing linkage to alcohol withdrawal severity were identified in a population of (C57BL/6J x DBA/2J)F2 animals (Buck et al 2002, J:91457). In this study the authors examined coding region variations between parental strains C57BL/6J and DBA/2J for a battery of genes located within the QTL intervals to identify possible candidates.
  
  A previously identified suggestive QTL mapped to 37 cM on mouse Chromosome 13 near D13Mit224 (LOD=2.9). DBA/2J-derived alleles confer increased alcohol withdrawal severity in male mice at this locus. 78 genes spanning 84,635 bp around this locus were screened for SNPs differing between C57BL/6J and DBA/2J. Thirty-six amino acid changes were identified in fifteen different genes. The genes identified as possible candidates are Habp4, Ptch1 (36 cM), Srd5a1 (39 cM), Zfp369 (formerly Nrif2), and Hsd17b3.