Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:93737 Lee NJ, et al., Multiple loci are linked with anti-red blood cell antibody production in NZB mice -- comparison with other phenotypes implies complex modes of action. Clin Exp Immunol. 2004 Oct;138(1):39-46
• ID
  MGI:3524769

Genes

Gene	Assay Type
Arigg6	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 222 female animals from a (NZB/BlNJ x BALB/cByJ)F2 intercross to identify QTLs associated with susceptibility to autoimmune hemolytic anemia (AHA) and systemic lupus erythematosus (SLE). 96 polymorphic markers at an average spacing of 17 cM were used in the genome scan. Parental strain NZB/BlNJ is susceptible to autoimmune hemolytic anemia and exhibits elevated serum levels of anti-red blood cell antibodies compared to BALB/cByJ. NZB/BlNJ is also susceptible to systemic lupus erythematosus and exhibits elevated serum levels of antinuclear antibodies compared to parental strain BALB/cByJ.
  
  On mouse Chromosome 6, linkage to anti-red blood cell IgG antibodies at 8 months of age mapped to 21.3 cM - 22 cM (P=3.9 x 10-3). This locus is named Arigg6 (anti-RBC IgG antibodies 6). NZB/BlNJ-derived alleles confer increased anti-red blood cell IgG antibodies at this locus. A previously identified lupus QTL named Lxw2 (25.5 cM) maps near Arigg6.