Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:94605 Cheverud JM, et al., Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes. 2004 Dec;53(12):3328-36
• ID
  MGI:3525653

Genes

Gene	Assay Type
Kdnw3	visible phenotype
D17Mit19	PCR amplified length variant
D17Mit115	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 16 LGXSM (LG=LG/J; SM=SM/J) recombinant inbred (RI) lines to identify QTLs associated with obesity and diabetes traits. Parental strain LG/J exhibits a larger body size compared to parental strain SM/J and these two strains also differ in obesity and diabetes related traits in response to dietary fat. 506 microsatellite markers at an average spacing of 2 to 3 cM were used in the genome scan. 39 loci were mapped but only those reaching genomewide significance are reportedhere.
  
  On mouse Chromosome 17, an interval between D17Mit19 (3 cM) and D17Mit115 (24.2 cM) shows linkage to kidney weight, adult body growth between 10-20 weeks of age, and cholesterol levels. This locus is named Kdnw3 (kidney weight 3). LG/J-derived alleles confer increased kidney weight, body growth, and cholesterol at Kdnw3.