Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:73097 Xie S, et al., Genetic contributions of nonautoimmune SWR mice toward lupus nephritis. J Immunol. 2001 Dec 15;167(12):7141-9
• ID
  MGI:3530037

Genes

Gene	Assay Type
D10Mit10	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 86 female animals from a NZB x (SWR x NZB)F1 backcross population to identify dominant SWR-derived QTLs associated with lupus phenotypes. (SWR x NZB)F1 hybrid animals are susceptible to lupus nephritis. 122 autosomal microsatellite markers at an average spacing of 10 cM were used for the genome scan.
  
  Suggestive linkage to early mortality mapped to 50 cM on mouse Chromosome 10 near D10Mit10 (LOD=1.62). NZB-derived alleles at D10Mit10 confer early mortality with recessive inheritance.