Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
• ID
  MGI:3530106

Genes

Gene	Assay Type
Eae27	resistance/susceptibility
D1Mit33	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 402 animals from a B10.RIII-H2^r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2^r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2^r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.
  
  Eae27 mapped to 81.6 cM on mouse Chromosome 1 near D1Mit33 (LRS=12.8). RIIIS/J-derived alleles at Eae27 appear to confer EAE resistance in female animals with a dominant mode of inheritance. Previously identified QTL mapping near Eae27 are Cia9 (92.3 cM), Stia1 (81.6 cM), and Orch4 (110 cM).