Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
• ID
  MGI:3530108

Genes

Gene	Assay Type
Eae39	resistance/susceptibility
D5Mit41	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 402 animals from a B10.RIII-H2^r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2^r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2^r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.
  
  Eae39 mapped to 56 cM on mouse Chromosome 5 near D5Mit41 (LRS=18). (Eae39 is referred to as Eae26 in this article.) RIIIS/J-derived alleles at Eae39 appear to confer EAE resistance in male animals with a dominant mode of inheritance. Previously identified QTLs mapping near Eae39 are Pgia16 (36 cM), Bbaa2 (66 cM), and Bbaa3 (45 cM).