Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:36093 Vyse TJ, et al., Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. J Clin Invest. 1996 Oct 15;98(8):1762-72
• ID
  MGI:3530799

Genes

Gene	Assay Type
Epb41	reported elsewhere
D4Mit48	PCR
Nba1	reported elsewhere
C1qa	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on a population of female (NZB/BlNJ x NZW/LacJ)F1 x NZW/BlNJ backcross animals to identify QTLs associated with autoimmune nephritis traits. Neither parental strains NZB/BlNJ nor NZW/LacJ develop severe nephritis. However, (NZB/BlNJ x NZW/LacJ)F1 hybrid animals do develop severe nephritis with several autoantibody traits. This study extends a previous nephritis mapping experiment using 60 female animals from the same kind of cross. In this study 48 additional female animalsand 9 microsatellite markers were added to the analysis.
  
  Suggestive linkage to nephritis mapped to mouse Chromosome 4 between Epb4.1 (65.7 cM, P=0.001) and D4Mit48 (69.8 cM, P=0.0006). This locus colocalizes with Nba1, a previously mapped autoimmunity QTL. A potential candidate gene for this locus is C1qa (66.1 cM).
  
  07.14.2015 Curator Note: Because Nba1 was originally mapped in J:18262 in 1994 using an identical cross to the backcross used here, and it mapped to the same genomic segment, we consider the QTL identified here to be the same QTL, Nba1.