Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  14
• Reference
  J:36093 Vyse TJ, et al., Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. J Clin Invest. 1996 Oct 15;98(8):1762-72
• ID
  MGI:3530814

Genes

Gene	Assay Type
D14Mit4	PCR
Tcra	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on a population of female (NZB/BlNJ x NZW/LacJ)F1 x NZW/BlNJ backcross animals to identify QTLs associated with autoimmune nephritis traits. Neither parental strains NZB/BlNJ nor NZW/LacJ develop severe nephritis. However, (NZB/BlNJ x NZW/LacJ)F1 hybrid animals do develop severe nephritis with several autoantibody traits. This study extends a previous nephritis mapping experiment using 60 female animals from the same kind of cross. In this study 48 additional female animalsand 9 microsatellite markers were added to the analysis.
  
  Suggestive linkage to anti-gp70 production mapped to 22 cM on mouse Chromosome 14 near D14Mit4 (LOD=2.02). The NZW/LacJ-derived allele confers increased anti-gp70 antibody production. A potential candidate gene for this locus is Tcra at around 19 cM.