Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:36093 Vyse TJ, et al., Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. J Clin Invest. 1996 Oct 15;98(8):1762-72
• ID
  MGI:3530815

Genes

Gene	Assay Type
D16Mit5	PCR

Notes

• Experiment
  Linkage analysis was performed on a population of female (NZB/BlNJ x NZW/LacJ)F1 x NZW/BlNJ backcross animals to identify QTLs associated with autoimmune nephritis traits. Neither parental strains NZB/BlNJ nor NZW/LacJ develop severe nephritis. However, (NZB/BlNJ x NZW/LacJ)F1 hybrid animals do develop severe nephritis with several autoantibody traits. This study extends a previous nephritis mapping experiment using 60 female animals from the same kind of cross. In this study 48 additional female animalsand 9 microsatellite markers were added to the analysis.
  
  Weak linkage to nephritis mapped to 32 cM on mouse Chromosome 16 near D16Mit5 (LOD=0.003). This locus also shows suggestive linkage to IgG anti-dsDNA and anti-histone antibody production. Homozygosity for NZW/LacJ-derived alleles confer increased antibody production at this locus