Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:36093 Vyse TJ, et al., Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. J Clin Invest. 1996 Oct 15;98(8):1762-72
• ID
  MGI:3530816

Genes

Gene	Assay Type
H2	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on a population of female (NZB/BlNJ x NZW/LacJ)F1 x NZW/BlNJ backcross animals to identify QTLs associated with autoimmune nephritis traits. Neither parental strains NZB/BlNJ nor NZW/LacJ develop severe nephritis. However, (NZB/BlNJ x NZW/LacJ)F1 hybrid animals do develop severe nephritis with several autoantibody traits. This study extends a previous nephritis mapping experiment using 60 female animals from the same kind of cross. In this study 48 additional female animalsand 9 microsatellite markers were added to the analysis.
  
  The strongest linkage to nephritis mapped to mouse Chromosome 17 near the H2 locus (P=0.0001). Animals heterozygous at this locus are susceptible to developing severe nephritis. This locus also shows linkage to gp70 immune complex (IC) levels (LOD=4.02). The NZB/BlNJ-derived allele appears to confer increased gp70 IC levels at this locus.