Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  1
• Reference
  J:96059 Oharaseki T, et al., Susceptibility Loci to Coronary Arteritis in Animal Model of Kawasaki Disease Induced with Candida albicans -Derived Substances. Microbiol Immunol. 2005;49(2):181-9
• ID
  MGI:3574906

Genes

Gene	Assay Type
D1Mit171	PCR
D1Mit245	PCR
Il1r1	reported elsewhere
Il1r2	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 115 (CBA/JNCrj x C3H/HeNCrj)F1 x C3H/HeNCrj backcross animals to identify QTLs associated with coronary arteritis. Parental strain C3H/HeNCrj is susceptible to arteritis and serves as a mouse model for Kawasaki disease. Arteritis was induced in 4-week old male backcross animals by intraperitoneal injection with Candida albicans-derived substances (CADS). 250 microsatellite markers were used for the genome scan.
  
  Suggestive linkage to arteritis mapped to 20.2 cM on mouse Chromosome 1 between D1Mit171 and D1Mit245 (P=0.0019). Two potential candidate genes mapping to this region are Il1r1 and Il1r2.