Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  11
• Reference
  J:97137 Evans SC, et al., A novel genetic modifier of p53, mop1, results in embryonic lethality. Mamm Genome. 2004 Jun;15(6):415-23
• ID
  MGI:3575567

Genes

Gene
Motp1
D11Mit90
Trp53

Notes

• Experiment
  Linkage analysis was performed on a population of (129-Trp53^tm1Tyj/J x CE/J)F2 intercross animals to identify modifiers of Trp53. Ratio distortion was observed in F2 animals with a significant decrease in the number of Trp53^tm1Tyj heterozygous and homozygous animals. A locus named Motp1 (modifier of Trp53 1) mapped to 42 cM on mouse Chromosome 11 near D11Mit90 with LOD=11.2. This locus is very close to the Trp53 locus (39 cM). Motp1 is a recessive modifier derived from the CE/J genetic background. Homozygosity for CE/J-derived alleles at Motp1 in conjunction with heterozygosity or homozygosity for Trp53^tm1Tyj confers increased embryonic lethality. Motp1 was also detected using backcross and congenic analysis, thus verifying its presence.
  
  Suggestive linkage to Trp53-dependent embryonic lethality was also detected at 35 cM on mouse Chromosome 6 near D6Mit9 (LOD=1.44) and at 38 cM on mouse Chromosome 16 near D16Mit5 (LOD=1.65).