Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• ID
  MGI:3578881

Genes

Gene	Assay Type
Bntq5	visible phenotype
Bntq6	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.
  
  A locus on mouse Chromosome 4 between 13 cM - 26 cM showed linkage to femur medullary area (LOD=3.9), CSMI, femur ultimate stress, and tibia ultimate load (LOD=4.5). This locus is named Bntq5 (bone traits QTL 5). A second interval between 30 cM - 48 cM showed linkage to tibia ultimate load (LOD=4.5) and stiffness. This locus is named Bntq6. Previously identified bone QTLs mapping near Bntq6 are Bmch2 (35 cM), Bmd7 (57.4 cM), and Fembm5 (66 cM).