Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• ID
  MGI:3578883

Genes

Gene	Assay Type
Bntq7	visible phenotype
Mitf	reported elsewhere
Gdf3	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.
  
  An interval on mouse Chromosome 6 between 40 cM - 70 cM showed linkage to neck ultimate displacement and femur sagittal width. This locus is named Bntq7 (bone traits QTL 7). Peak linkage occurs at 46 cM for neck ultimate displacement in male animals (LOD=5.6). Potential candidate genes mapping near Bntq7 are Mitf (40 cM) and Gdf3 (60.6 cM).