Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• ID
  MGI:3578894

Genes

Gene	Assay Type
Bntq13	visible phenotype
Fos	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.
  
  An interval on mouse Chromosome 12 from 47 cM - 57 cM showed linkage to femur head diameter. This locus in named Bntq13 (bone traits QTL 13) and is also associated with several other bone phenotypes, such as tibia CSMI, tibia cortical area, and tibia medullary area. Peak linkage occurred at 53 cM with LOD= 5.6. A previously identified bone QTL mapping near Bntq13 is Vtbt14 at 53 cM. A potential candidate gene for Bntq13 is Fos at 40 cM.