Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  17
• Reference
  J:89010 Paffenholz R, et al., Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev. 2004 Mar 1;18(5):486-91
• ID
  MGI:3579558

Genes

Gene
Nox3
Tiam2
D17Ingm4
D17Ingm9
D17Brg18
D17Brg198

Notes

• Experiment
  The head-tilt R96 (hetR96) mutation was mapped to an interval on proximal mouse Chromosome 17 between D17Ing9 and the centromere using 375 (C3HeB/FeJ-Nox3^het-R96 x C57BL/6J)F2 intercross animals. BAC clone RP23-27N1 was found to carry the gene as evidenced by BAC transgenic rescue experiments. This clone carries the following candidate genes in descending order from the centromere: Racgef1 - Tiam2 - Cldn20 - Nox3. Sequence analysis revealed a premature stop mutation in the Nox3 gene in hetR96 animals.
  
  (Racgef1 and Cldn20 do not exist in MGI as of 6/14/05)