Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:98187 Pomerleau DP, et al., Major Histocompatibility Complex-Linked Diabetes Susceptibility in NOD/Lt Mice: Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2g7 Complex. Diabetes. 2005 May;54(5):1603-6
• ID
  MGI:3579887

Genes

Gene	Assay Type
Idd16.1	resistance/susceptibility
D17Mit13	PCR
H2-D	reported elsewhere
Tnf	reported elsewhere
Idd16.2	resistance/susceptibility
D17Mit16	PCR

Notes

• Experiment
  Analysis of interval specific congenic lines resolved the Idd16 diabetes QTL into two distinct loci named Idd16a and Idd16b. ALR/LtJ-derived portions of the Idd16 locus were introgressed onto the genetic background of NOD/LtJ. Parental strain ALR/LtJ is resistant to insulin-dependent (type 1) diabetes whereas parental strain NOD/LtJ is susceptible. Three different subcongenic lines were contructed.
  
  Idd16a is localized to the distal portion of the original Idd16 QTL interval between D17Mit13 (19.06 cM) and H2-D (19.09 cM). The ALR/LtJ-derived allele of Idd16a appears to slow insulitis progression, but not its prevention. Potential candidate genes for Idd16a are Tnf (19.06 cM) and H2-D^dx (19 cM). The latter is considered a stronger candidate gene since serum levels of Tnf do not differ between NOD/LtJ and ALR/LtJ. The H2-D^dx allele is thought to be involved in resistance to type 1 diabetes.
  
  Idd16b is localized to the proximal portion of the original Idd16 QTL interval above D17Mit16. Idd16b is involved in resistance to diabetogenesis.