Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  13
• Reference
  J:90701 Ahituv N, et al., An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome. 2004 Jun;15(6):424-32
• ID
  MGI:3580147

Genes

Gene
Tfap2a

Notes

• Experiment
  The Dorad mutation was mapped to an interval on mouse Chromosome 13 between D13Mit88 (21 cM) and D13Mit94 (31 cM) using 53 Dor+/- animals from a (C3HeB/FeJ-Dor x C57BL/6J)F1 x C3HeB/FeJ backcross. This region contains 8 candidate genes but Tcfap2a is theonly candidate gene with sequence variation between Dor mutants and wild type. An amino acid change (P59L) in the Tcfap2a coding sequence is found in Dor mutants. Furthermore, homozygous knockout Tcfap2a^tm1Will animals exhibit a phenotype similar to Dor mutants.