Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:98477 Gill KJ, et al., Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav Brain Res. 2005 Jun 3;161(1):113-24
• ID
  MGI:3580551

Genes

Gene	Assay Type
Nsila1	visible phenotype
D1Mit136	PCR
Htr5b	reported elsewhere

Notes

• Experiment
  QTLs associated with novelty/stress-induced locomotor activation were mapped using a series of recombinant inbred (RI) and recombinant congenic (RC) strains derived from C57BL/6J and A/J progenitor strains. Progenitor strain C57BL/6J exhibits greater activation of locomotor activity when placed in a novel open field environment compared to progenitor strain A/J. 1159 animals from the AXB/BXA RI series were genotyped with a panel of 780 polymorphic markers. 13 AcB and 31 BcA RC strains were genotyped witha panel of 625 polymorphic markers.
  
  An interval on mouse Chromosome 1 between 58.1 cM - 63.1 cM showed suggestive linkage to locomotor activation in a novel environment. Marker D1Mit26 at 62.1 cM showed peak linkage in the AXB/BXA RI population and marker D1Mit136 at 59.6 cM showed peak linkage in the BcA RC population. Since this locus was detected in 2 different crosses it is assigned the QTL symbol Nsial1 (novelty/stress induced locomotor activation 1). C57BL/6J-derived alleles at Nsila1 confer increased locomotor activation in a novel environment. This interval was also detected in previous mapping experiments as evidenced by overlap with several other behavioral QTLs such as Lrnx1 (60.8 cM), Lrnx12 (65 cM), and Actd1 (65 cM). A potential candidate gene for Nsial1 is Htr5b at 63 cM.