Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:98477 Gill KJ, et al., Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav Brain Res. 2005 Jun 3;161(1):113-24
• ID
  MGI:3580552

Genes

Gene	Assay Type
Nsila2	visible phenotype
D3Mit185	PCR
Nsila3	visible phenotype
D3Mit110	PCR
Hnl	reported elsewhere

Notes

• Experiment
  QTLs associated with novelty/stress-induced locomotor activation were mapped using a series of recombinant inbred (RI) and recombinant congenic (RC) strains derived from C57BL/6J and A/J progenitor strains. Progenitor strain C57BL/6J exhibits greater activation of locomotor activity when placed in a novel open field environment compared to progenitor strain A/J. 1159 animals from the AXB/BXA RI series were genotyped with a panel of 780 polymorphic markers. 13 AcB and 31 BcA RC strains were genotyped witha panel of 625 polymorphic markers.
  
  In the AcB/BcA RC population, a locus at 29.5 cM on mouse Chromosome 3 near D3Mit185 showed significant linkage to locomotor activation in a novel environment. This locus is designated Nsila2 (novelty/stress induced locomotor activation 2). The C57BL/6J-derived allele at Nsila2 is associated with increased novelty/stress induced activation of locomotor activity. A second locus with significant linkage to locomotor activation mapped to 64.1 cM near D3Mit110. The QTL interval spans 64.1 cM - 76.2 cM. This locus is designated Nsila3 (novelty/stress induced locomotor activation 3). The A/J-derived allele at Nsila3 is associated with increased novelty/stress induced activation of locomotor activity. A potential candidate gene mapping near Nsila3 is Hnl (63.7 cM).