Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:98477 Gill KJ, et al., Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav Brain Res. 2005 Jun 3;161(1):113-24
• ID
  MGI:3580553

Genes

Gene	Assay Type
Nsila4	visible phenotype
D5Mit356	PCR
Gabra2	reported elsewhere

Notes

• Experiment
  QTLs associated with novelty/stress-induced locomotor activation were mapped using a series of recombinant inbred (RI) and recombinant congenic (RC) strains derived from C57BL/6J and A/J progenitor strains. Progenitor strain C57BL/6J exhibits greater activation of locomotor activity when placed in a novel open field environment compared to progenitor strain A/J. 1159 animals from the AXB/BXA RI series were genotyped with a panel of 780 polymorphic markers. 13 AcB and 31 BcA RC strains were genotyped witha panel of 625 polymorphic markers.
  
  In the AXB/BXA RI population, a locus at 41 cM on mouse Chromosome 5 near D5Mit356 (LOD=4.3) showed significant linkage to locomotor activation in a novel environment. This locus was also detected in the BcA RC population and is designated Nsila4 (novelty/stress induced locomotor activation 4). The Nsila4 QTL interval spans 19 cM - 45 cM. The C57BL/6J-erived allele at Nsila4 is associated with increased novelty/stress induced activation of locomotor activity. A potential candidate gene mapping to the Nsila4 interval is Gabra2 (40 cM).