Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:98292 Garlow SJ, et al., Genetic analysis of the hypothalamic corticotropin-releasing factor system. Endocrinology. 2005 May;146(5):2362-8
• ID
  MGI:3580602

Genes

Gene	Assay Type
Crhtaq2	visible phenotype
D12Mit280	PCR
Avptaq2	visible phenotype
D12Mit136	PCR
Crhr1taq2	visible phenotype
D12Mit5	PCR
Ckb	reported elsewhere

Notes

• Experiment
  QTLs linked to the trans regulation of genes involved in the corticotropin-releasing factor system were mapped using male animals from 28 BXD recombinant inbred lines (B=C57BL/6J; D=DBA/2J). Transcript abundance of Crh, Crhr1, Crhbp, and Avp were used asquantitative traits. Parental strain DBA/2J exhibits lower transcript abundance of all 4 genes compared to parental strain C57BL/6J. A panel of 975 polymorphic loci was used for linkage analysis.
  
  Significant linkage to Crh expression mapped to mouse Chromosome 12 between 54 cM and 55 cM (D12Mit280). This locus is named Crhtaq2 (Crh transcript abundance QTL 2), and the 95% confidence interval of Crhtaq2 spans 19 cM. A potential candidate gene mapping near Crhtaq2 is Ckb (55 cM). Dps2 (55 cM) is a previously identified QTL mapping near Crhtaq2. Significant linkage to Avp expression mapped to 13 cM on chromosome 12 near D12Mit136. This locus is named Avptaq2 (Avp transcript abundance QTL 2), and the 95% confidence interval spans 22 cM. Suggestive linkage to Crhbp expression maps near this locus at 19 cM. Significant linkage to Crhr1 expression maps to 37 cM near D12Mit5. This locus is named Crhr1taq2 (Crhr1 transcript abundance QTL 2), and the 95% confidence interval spans 43 cM.