Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:98150 Haraldsson MK, et al., Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice. J Immunol. 2005 Apr 15;174(8):5065-73
• ID
  MGI:3580623

Genes

Gene	Assay Type
Lbw2	resistance/susceptibility
D4Mit203	PCR
D4Mit70	PCR
D4Mit169	PCR
D4Nds2	PCR

Notes

• Experiment
  The Lbw2 QTL interval on mouse Chromosome 4 was refined to a 2.3 cM region between D4Mit203 (60 cM) and D4Mit70 (62.3 cM). (NZB x NZB.NZW-Lbw2)F1 x NZW animals were generated for phenotype analysis. Animals that lacked the NZB-derived Lbw2 locus exhibit increased survival compared to heterozygous animals. Edema, proteinuria, and IgM and IgG deposits were also decreased in the glomeruli of animals lacking NZB-derived alleles at Lbw2. IgM anti-ssDNA autoantibodies were decreased in animals lacking NZB-derived alleles at Lbw2. One or two copies of the NZB-derived Lbw2 locus is associated with increased spleen weight and mortality, indicating a dominant mode of inheritance.
  
  Linkage analysis was performed on a population of 145 (NZB x NZW)F2 animals. The Lbw2 locus showed association with accelerated mortality and increased IgM anti-chromatin antibody production when derived from NZB. The region of peak linkage was between D4Mit169 (58 cM) and D4Nds2 (42.6 cM).
  
  No candidate genes for Lbw2 were cited in this study. Previously identified autoimmunity QTLs mapping near Lbw2 are Sle2 (38 cM) and Adaz1 (49.6 cM).