Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:98145 Rolf J, et al., The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11. J Immunol. 2005 Apr 15;174(8):4821-7
• ID
  MGI:3580625

Genes

Gene	Assay Type
Idd11	resistance/susceptibility
Idd9	resistance/susceptibility
D4Mit72	PCR
D4Mit251	PCR

Notes

• Experiment
  Linkage analysis was performed on 192 animals from a (NOD/Bom x C57BL/6J)F2 intercross to map QTLs associated with B cell phenotypes. 119 polymorphic markers at an average spacing of 15 cM were used in the genome scan. Parental strain NOD/Bom is susceptible to type 1 diabetes and exhibits an expanded marginal zone (MZ) B cell population compared to the diabetes resistant parental strain C57BL/6J.
  
  Peak linkage to CD21high B cell subsets mapped to 59.9 cM on mouse Chromosome 4 near D4Mit72 with LOD=4.4. This locus coincides with previously mapped diabetes QTL Idd11 (64.6 cM) and maps near previously identified QTL Idd9 (82 cM). The QTL interval spans a 7 cM region between D4Mit72 and D4Mit251 (66 cM) and explains approximately 12% of the phenotypic variance. Other previously identified QTLs mapping near Idd11 are Lbm1 (57.5 cM), Lbw2 (55.6 cM), and Sbw2 (44.5 cM).
  
  Suggestive linkage to CD21high B cell subsets mapped to mouse Chromosome 1 (D1Mit498), mouse Chromosome 4 (D4Mit235), mouse Chromosome 9 (D9Mit205), and mouse Chromosome 19 (D19Mit91).