Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:84296 Bergman ML, et al., Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains. Diabetes. 2003 Jul;52(7):1677-82
• ID
  MGI:3581691

Genes

Gene	Assay Type
Idd6	resistance/susceptibility
D6Mit14	PCR
D6Mit15	PCR
D6Mit340	PCR
D6Mit304	PCR
Clec4n	reported elsewhere

Notes

• Experiment
  Previous studies have shown linkage between the Idd6 locus and apoptosis resistance in immature thymocytes after gamma-irradiation. Idd6 locus also appears to be linked to apoptosis resistance after dexamethazone treatment. To confirm this observation linkage analysis was performed on 72 dexamethazone-treated female animals from a (C57BL/6 x NOD)F2 intercross. Peak association to dexamethazone-induced thymocyte depletion mapped to the Idd6 locus with LOD=6.5 between D6Mit14 (71.2 cM) and D6Mit15 (74 cM) on mouse Chromosome 6. Linkage to apoptosis resistance occurs in the same region with LOD=3.5. NOD-derived alleles at Idd6 confer resistance to apoptosis resistance in a dominant manner. This locus explains 34% of the phenotypic variation.
  
  Construction of a congenic line by introgression of a C57BL/6-derived locus containing Idd6 on an NOD genetic background rescues the apoptosis phenotype. The Idd6 congenic interval controlling dexamethazone-induced apoptosis resistance of immature thymocytes was localized to a 3 cM region between D6Mit340 (72 cM) and D6Mit304 (75 cM). The natural killer complex, Nkcl at 57 cM is a possible candidate for Idd6. Two previously identified insulin-dependent diabetes QTLs, Idd19 (60.5 cM) and Idd20 (37.7 cM), also map to mouse Chromosome 6.